Possible Mechanisms of SARS-CoV2-Mediated Myocardial Injury

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has rapidly become a global health emergency. In addition to causing effects, SARS-CoV-2 can result in cardiac involvement leading myocardial damage, which is increasingly being explored the literature. Myocardial injury an important pathogenic feature of COVID-19. The angiotensin-converting enzyme-2 receptor plays key role pathogenesis virus, serving as “bridge” allowing invade body. However, exact mechanism underlying how causes remains unclear. This review summarizes main possible mechanisms patients with COVID-19, including direct cell injury, microvascular dysfunction, cytokine responses and systemic inflammation, hypoxemia, stress responses, drug-induced injury. Understanding would aid proper identification treatment